e. Discussion
i. Listing IBW next to height weight and name in top banner has helped some sites.
(Dr. Berris – Beaumont Farmington Hills)
ii. Adolescent population can be a challenge, due to variation in height
iii. Have not experienced any unintended consequences of the PUL 02 measure
where cases that should have been flagged were not. *To all QC members,
please reach out if with any discrepancies you find in any of the measures.
7. Measure Feedback: PONV-01 (MIPS-430)
a. Add palonosetron to the 5HT3 antiemetic group that currently contains ondansetron,
dolansetron, and granisetron
i. Included due to supply shortage of other anti-emetic medications at this time
b. Add propofol given after induction as an anti-emetic (Proposed by Dr. Tim Harwood at
Wake Forest)
c. Add metoclopramide as an anti-emetic (also proposed by Dr. Tim Harwood from Wake
Forest)
i. Review from 2014 co-authored by TJ Gan found that Metoclopramide is effective
at 20 mg or higher as a non-sedating medication that helps to prevent PONV and
quicker hospital discharge as a result.
ii. Metoclopramide is a weak antiemetic and at a dose of 10 mg is not effective in
reducing the incidence of nausea and vomiting
iii. In a study with >3000 patients, metoclopramide had an antiemetic effect when
given in doses larger than 20 mg.
iv. Metoclopramide’s dose-response curve was evaluated in the presence of
dexamethasone 8 mg IV administered 30 to 60 minutes before the end of
surgery.
v. Metoclopramide in 25 and 50 mg doses had an effect similar to ondansetron 4
mg for early PONV but a smaller effect than ondansetron for late PONV.
vi. The NNT for metoclopramide 10, 25, and 50 mg for PONV at 24 hours is 30, 16,
and 11, respectively.
vii. Dyskinesia or extrapyramidal symptoms were 0.3%, 0.6%, and 0.6%, respectively,
and can increase with increasing metoclopramide doses.
viii. The NNH for extrapyramidal symptoms with the 25 or 50 mg doses is 140.35
ix. Discussion:
1. MPOG will query to see which sites use metoclopramide preoperatively
and to what extent
2. Plan to provide this feedback to ASA. Need to mutually agree with ASA
on this modification as this is a MIPS measure.
3. There are a lot of ways to prevent PONV that are not captured by ASPIRE.
How does MPOG plan to capture agents given prior to anesthesia start?
(Dr. Nirav Kamdar– UCLA)